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Last Updated: 04/01/24

Available Agents

Click on column header to sort by Agent Name, Company or Agent Class

Agent Name NSC Number Company Agent Class Agent Target/Molecular Target(s)
Abemaciclib 783671 Eli Lilly and Company CDK4/6 Inhibitor CDK4, CDK6
Alectinib 794611 Genentech ALK inhibitor, tyrosine kinase inhibitor ALK, RET
Atezolizumab 783608 Genentech PD-L1 blocking monoclonal antibody PD-L1
Avelumab 799232 EMD Serono, Inc. PD-L1 Inhibitor PD-L1
Bevacizumab 704865 Genentech Anti-angiogenesis inhibitor, monoclonal antibody VEGF
Blinatumomab 765986 Amgen Inc Bispecific T-cell engager (BiTE) monoclonal antibody CD3, CD19
Capivasertib 782347 AstraZeneca serine/threonine kinase (AKT) inhibitor AKT 1, AKT 2, AKT 3
Ceralasertib 802785 AstraZeneca ATR kinase inhibitor ATR
Cobimetinib 781257 Genentech MEK1/2 inhibitor MEK1/2
Durvalumab 778709 AstraZeneca PD-L1 blocking monoclonal antibody PD-L1, CD80
Elzovantinib Turning Point Therapeutics Small (low molecular weight), macrocyclic tyrosine kinase inhibitor MET, SRC, CSF1R
Ensartinib 784729 Xcovery Holding Company LLC ALK inhibitor ALK, TrkA, TrkC, ROS, EphA2, c-MET
Giredestrant 840836 Genentech Selective estrogen receptor degrader (SERD) ER-targeting therapy
Glofitamab 845088 Genentech Bispecific monoclonal antibody CD20 expressed on the surface of B cells and CD3 receptor expressed on the surface of T cells.
Inavolisib 843575 Genentech Class I PI3Kα Class I PI3Kα isoform (p110α)
Ipilimumab 732442 Bristol-Myers Squibb anti-CTLA-4 monoclonal anibody CTLA-4
Larotrectinib 788607 Bayer Tyrosine kinase inhibitor NTRK-1, NTRK-2, NTRK-3 gene fusions; TrkA/B/C fusion proteins
Mirdametinib SpringWorks Therapeutics, Inc. MEK1/2 inhibitor MEK1, MEK2
Mogamulizumab 791064 Kyowa Hakko Kirin Co., Ltd. anti-CCR4 monoclonal antibody CC chemokine receptor 4 (CCR4)-expressing cells
Nirogacestat 811402 SpringWorks Therapeutics, Inc. Gamma Secretase Inhibitor Gamma Secretase
Nivolumab 748726 Bristol-Myers Squibb PD-1 blocking monoclonal antibody PD-1
Obinutuzumab 793436 Genentech anti-CD20 monoclonal antibody CD20
Olaparib 747856 AstraZeneca PARP inhibitor PARP-1, PARP-2, PARP-3
Pertuzumab 740102 Genentech anti-HER2 monoclonal antibody HER2/neu
Pertuzumab/trastuzumab/
hyaluronidase-zzxf
827796 Genentech Fully human immunoglobulin monoclonal antibodies Human epidermal growth factor receptor 2 (HER2, also known as c-erbB-2)
Regorafenib 821745 Bayer L01XE21 VEGFR1, VEGFR2, VEGFR3, TIE2, PDGFRB, FGFR1, KIT, RET, RAF1, BRAF
Repotrectinib Turning Point Therapeutics Small (low molecular weight), macrocyclic tyrosine kinase inhibitor ROS1, TRK, ALK, JAK, FAK, SRC
Savolitinib 785348 AstraZeneca MET kinase inhibitor MET
Selpercatinib 812076 Eli Lilly and Compnay Selective RET Inhibitor RET
SX-682   Syntrix Biosystems, Inc. CXCR1 and CXCR2 inhibitor CXCR1 and CXCR2 expressing cells
Talimogene laherparepvec 785349 Amgen Inc Genetically modified oncolytic virus  
Tiragolumab 827799 Genentech Fully human immunoglobulin monoclonal antibody T-Cells and natural killer (NK) cell subsets
Trastuzumab 688097 Genentech anti-HER2 monoclonal antibody HER2/neu
Trastuzumab and hyaluronidase-oysk 827797 Genentech Fully human immunoglobulin monoclonal antibody Human epidermal growth factor receptor 2 (HER2, also known as c-erbB-2)
Tremelimumab 744483 AstraZeneca anti-CTLA-4 monoclonal anibody CTLA-4