Available Agents

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Agent Name	NSC Number	Company	Agent Class	Agent Target/Molecular Target(s)
Abemaciclib	783671	Eli Lilly and Company	CDK4/6 Inhibitor	CDK4, CDK6
Adavosertib	751084	AstraZeneca	WEE1 kinase inhibitor	WEE1
Alectinib	794611	Genentech	ALK inhibitor, tyrosine kinase inhibitor	ALK, RET
Atezolizumab	783608	Genentech	PD-L1 blocking monoclonal antibody	PD-L1
Avelumab	799232	EMD Serono, Inc.	PD-L1 Inhibitor	PD-L1
Bevacizumab	704865	Genentech	Anti-angiogenesis inhibitor, monoclonal antibody	VEGF
Blinatumomab	765986	Amgen Inc	Bispecific T-cell engager (BiTE) monoclonal antibody	CD3, CD19
Capivasertib	782347	AstraZeneca	serine/threonine kinase (AKT) inhibitor	AKT 1, AKT 2, AKT 3
Cediranib	732208	AstraZeneca	VEGF RTK inhibitor	VEGFR-1, VEGFR-2, VEGFR-3, c-Kit
Ceralasertib	802785	AstraZeneca	ATR kinase inhibitor	ATR
Cobimetinib	781257	Genentech	MEK1/2 inhibitor	MEK1/2
Durvalumab	778709	AstraZeneca	PD-L1 blocking monoclonal antibody	PD-L1, CD80
Elzovantinib		Turning Point Therapeutics	Small (low molecular weight), macrocyclic tyrosine kinase inhibitor	MET, SRC, CSF1R
Ensartinib	784729	Xcovery Holding Company LLC	ALK inhibitor	ALK, TrkA, TrkC, ROS, EphA2, c-MET
Ipilimumab	732442	Bristol-Myers Squibb	anti-CTLA-4 monoclonal anibody	CTLA-4
Larotrectinib	788607	Bayer	Tyrosine kinase inhibitor	NTRK-1, NTRK-2, NTRK-3 gene fusions; TrkA/B/C fusion proteins
Mirdametinib		SpringWorks Therapeutics, Inc.	MEK1/2 inhibitor	MEK1, MEK2
Mogamulizumab	791064	Kyowa Hakko Kirin Co., Ltd.	anti-CCR4 monoclonal antibody	CC chemokine receptor 4 (CCR4)-expressing cells
Nivolumab	748726	Bristol-Myers Squibb	PD-1 blocking monoclonal antibody	PD-1
Obinutuzumab	793436	Genentech	anti-CD20 monoclonal antibody	CD20
Olaparib	747856	AstraZeneca	PARP inhibitor	PARP-1, PARP-2, PARP-3
Pertuzumab	740102	Genentech	anti-HER2 monoclonal antibody	HER2/neu
Regorafenib	821745	Bayer	L01XE21	VEGFR1, VEGFR2, VEGFR3, TIE2, PDGFRB, FGFR1, KIT, RET, RAF1, BRAF
Repotrectinib		Turning Point Therapeutics	Small (low molecular weight), macrocyclic tyrosine kinase inhibitor	ROS1, TRK, ALK, JAK, FAK, SRC
Savolitinib	785348	AstraZeneca	MET kinase inhibitor	MET
Selpercatinib	812076	Eli Lilly and Compnay	Selective RET Inhibitor	RET
SX-682		Syntrix Biosystems, Inc.	CXCR1 and CXCR2 inhibitor	CXCR1 and CXCR2 expressing cells
Talimogene laherparepvec	785349	Amgen Inc	Genetically modified oncolytic virus
Trastuzumab	688097	Genentech	anti-HER2 monoclonal antibody	HER2/neu
Tremelimumab	744483	AstraZeneca	anti-CTLA-4 monoclonal anibody	CTLA-4
Vemurafenib	761431	Genentech	BRAF mutant v600 inhibitor	BRAF V600 mutant, CRAF, ARAF, wild-type BRAF, SRMS, ACK1, MAP4K5, FGR